Balancing risks and benefits of cannabis use: umbrella review of meta-analyses of randomised controlled trials and observational studies (Canada)

A groundbreaking Canadian umbrella review spanning 2008 to 2022 examined 101 meta-analysis of cannabis studies, revealing associations with poor mental health, impaired cognition, increased motor vehicle accident risk, and potential harm to offspring during pregnancy. The umbrella review emphasises the avoidance of cannabis, particularly in neurodevelopmentally critical phases like adolescence. Given the onset of mental health disorders and the paramount role of cognition in academic performance during this period, caution is urged. Additionally, medical cannabis warrants scrutiny due to adverse effects, urging a careful risk-to-benefit evaluation before considering its incorporation.